Grill Lab
Laboratory of Regulatory Systems Neuroscience
University of Pennsylvania
Publications
Borner, T., Wald H.S., Ghidewon M.Y., Zhang B., Wu Z., De Jonghe B.C., Breen D., Grill H.J. (2020) GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss. Cell Reports.
Stein L.M, Lhamo R., Cao A., Workinger J., Tinsley I., Doyle R.P., Grill H.J., Hermann G.E. Rogers R.C. and Hayes M.R.(2020) Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation. Translational Psychiatry.
Borner T., Shaulson E.D., Ghidewon M.Y., Barnett A.B., Horn C.C., Doyle R.P., Grill H.J., Hayes M.R., De Jonghe B.C. (2020) GDF15 Induces Anorexia through Nausea and Emesis. Cell Metabolism.
Müller T.D., Finan B., Bloom S.R., D'Alessio D., Drucker D.J., Flatt P.R., Fritsche A., Gribble F., Grill H.J., Habener J.F., Holst J.J., Langhans W, Meier JJ, Nauck MA, Perez-Tilve D., Pocai A., Reimann F., Sandoval D.A., Schwartz T.W., Seeley R.J., Stemmer K., Tang-Christensen M., Woods S.C., DiMarchi R.D., Tschöp M.H. (2019). Glucagon-like peptide 1 (GLP-1). Molecular Metabolism
Alhadeff A.L., Conway S.M., Ong Z.Y., Wald H.S., Roitman M.F., Grill H.J. (2019) Central leptin signaling transmits positive valence. Brain Research.
Wald H.S., Grill H.J. (2019) Individual Differences in Behavioral Responses to Palatable Food or to Cholecystokinin Predict Subsequent Diet-Induced Obesity. Obesity.
Mishra D., Richard J.E., Maric I., Porteiro B., Häring M., Kooijman S., Musovic S., Eerola K., López-Ferreras L., Peris E., Grycel K., Shevchouk O.T., Micallef P., Olofsson C.S., Wernstedt Asterholm I., Grill H.J., Nogueiras R., Skibicka K.P. (2019) Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism. Cell Reports.
Ong, Z.Y., Liu, J.J., Pang, Z.P., Grill, H.J. (2017) Paraventricular Thalamic Control of Food Intake and Reward: Role of Glucagon-Like Peptide-1 Receptor Signaling. Neuropsychopharmacology.
Davis, X.S., Grill, H.J. (2018) The hindbrain is a site of energy balance action for prolactin-releasing peptide: feeding and thermic effects from GPR10 stimulation of the nucleus tractus solitarius/area postrema. Psychopharmacology.
Ong, Z.Y., Liu, J.J., Pang, Z.P., Grill, H.J. (2017) Paraventricular Thalamic Control of Food Intake and Reward: Role of Glucagon-Like Peptide-1 Receptor Signaling. Neuropsychopharmacology.
Ong, Z. Y., Bongiorno, D. M., Hernando, M. A., & Grill, H. J. (2017). Effects of endogenous oxytocin receptor signaling in nucleus tractus solitarius on satiation-mediated feeding and thermogenic control in male rats. Endocrinology.
Alhadeff, A. L., Holland, R. A., Zheng, H., Rinaman, L., Grill, H. J., & De Jonghe, B. C. (2017). Excitatory Hindbrain–Forebrain Communication Is Required for Cisplatin-Induced Anorexia and Weight Loss. Journal of Neuroscience, 37(2), 362-370.
Gerth, A. I., Alhadeff, A. L., Grill, H. J., & Roitman, M. F. (2017). Regional influence of cocaine on evoked dopamine release in the nucleus accumbens core: A role for the caudal brainstem. Brain Research, 1655, 252-260.
Alhadeff, A. L., Mergler, B. D., Zimmer, D. J., Turner, C. A., Reiner, D. J., Schmidt, H. D., ... & Hayes, M. R. (2016). Endogenous Glucagon-like Peptide-1 Receptor Signaling in the Nucleus Tractus Solitarius is Required for Food Intake Control. Neuropsychopharmacology.
Kanoski SE, Grill HJ, (2015). Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms. Biol Psychiatry
Grill HJ, Levine AS (2015). Tim Bartness, Ph.D (1953-2015). Obesity
Alhadeff AL, Holland RA, Nelson A, Grill HJ, De Jonghe BC (2015). Glutamate Receptors in the Central Nucleus of the Amygdala Mediate Cisplatin-Induced Malaise and Energy Balance Dysregulation through Direct Hindbrain Projections. J Neurosci
Ong ZY, Alhadeff AL, Grill HJ (2015). Medial Nucleus Tractus Solitarious Oxytocin Receptor Signaling and Food Intake Control: The Role of Gastrointestinal Satiation Signal Processing. Am J Physiol Regul Integr Comp Physiol
Kanoski SE, Ong ZY, Fortin SM, Schlessinger ES, Grill HJ (2015). Liraglutide, leptin, and their combined effects on feeding: additive intake reduction through common intracellular signaling mechanisms. Diabetes, Obesity and Metabolism.
Ozek C, Kanoski SE, Zhang ZY, Grill HJ, Bence KK (2014). Protein-tyrosine Phosphatase 1B (PTP1B) Is a Novel Regulator of Central Brain-derived Neurotrophic Factor and Tropomyosin Receptor Kinase B (TrkB) Signaling. J Biol Chem.
Alhadeff AL, Hayes MR, Grill HJ (2014). Leptin receptor signaling in the lateral parabrachial nucleus contributes to the control of food intake. Am J Physiol Regul Integr Comp Physiol. 307(11):R1338-44
Alhadeff AL and Grill HJ (2014). Nucleus tractus solitarius glucagon-like peptide-1 receptor signaling reduces appetitive and motivational aspects of feeding. Am J Physiol Regul Integr Comp Physiol. 307(4):R465-70.
Kanoski SE, Alhadeff AL, Fortin SM, Gilbert JR, Grill HJ (2014). Leptin Signaling in the Medial Nucleus Tractus Solitarius Reduces Food Seeking and Willingness to Work for Food. Neuropsychopharmacology. 39(3):605-13.
Kanoski SE, Fortin SM, Ricks KM, Grill HJ (2013). Ghrelin signaling in the ventral hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling. Biol Psychiatry. 73(9):915-23.
Kanoski, SE, Fortin SM, Ricks KM, Grill HJ (2013). Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling. Biol Psychiatry. 73(9):915-23.
Skibicka, KP, Alhadeff AL, Leichner TM, Grill HJ (2011). Neural controls of prostaglandin 2 pyrogenic, tachycardic, and anorexic actions are anatomically distributed.. Endocrinology. 152((6)):2400-8.
Hayes, MR, Leichner TM, Zhao S, Lee GS, Chowansky A, Zimmer D, Jonghe BCD, Kanoski SE, Grill HJ (2011). Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell Metabolism. 13(3):320-30.